<th id="fxuvs"><meter id="fxuvs"><dfn id="fxuvs"></dfn></meter></th>
    <track id="fxuvs"></track><th id="fxuvs"></th>
    <span id="fxuvs"><big id="fxuvs"><sub id="fxuvs"></sub></big></span>
    <sub id="fxuvs"></sub>
      <track id="fxuvs"></track><th id="fxuvs"><meter id="fxuvs"></meter></th>

        <th id="fxuvs"><meter id="fxuvs"><listing id="fxuvs"></listing></meter></th>

                  <th id="fxuvs"><meter id="fxuvs"></meter></th>

                  <th id="fxuvs"><meter id="fxuvs"><listing id="fxuvs"></listing></meter></th>

                  <th id="fxuvs"><progress id="fxuvs"></progress></th>

                      <address id="fxuvs"><big id="fxuvs"></big></address>

                      <th id="fxuvs"></th>

                      <nobr id="fxuvs"></nobr>

                      <thead id="fxuvs"><meter id="fxuvs"></meter></thead>
                      <track id="fxuvs"></track>

                      <sub id="fxuvs"></sub>

                      <track id="fxuvs"></track>

                      <track id="fxuvs"><form id="fxuvs"></form></track>

                      <sup id="fxuvs"><ins id="fxuvs"></ins></sup>
                      <dl id="fxuvs"><ins id="fxuvs"></ins></dl>

                      <div id="fxuvs"><tr id="fxuvs"><mark id="fxuvs"></mark></tr></div>

                      <sup id="fxuvs"></sup>

                      <dfn id="fxuvs"><tr id="fxuvs"></tr></dfn>
                      <div id="fxuvs"></div><sup id="fxuvs"></sup>
                      <em id="fxuvs"></em>

                      <em id="fxuvs"><ins id="fxuvs"></ins></em>

                          <div id="fxuvs"><tr id="fxuvs"></tr></div>

                            <em id="fxuvs"></em>

                            <dl id="fxuvs"><menu id="fxuvs"><form id="fxuvs"></form></menu></dl><div id="fxuvs"></div>
                                <sup id="fxuvs"><menu id="fxuvs"></menu></sup>
                                <div id="fxuvs"><tr id="fxuvs"></tr></div>

                                <sup id="fxuvs"></sup><div id="fxuvs"></div>

                                <sup id="fxuvs"><meter id="fxuvs"></meter></sup>
                                登录 |注册 |?#19994;?#36141;物车 |用户中心 |快速购买 |批量查询 |微博 | 微信关注 |收藏本站 中文 English
                                购物车
                                您现在的位置: 首页 > 生化试剂 > 激动剂抑制剂 > 免疫学和炎症 > 其它免疫和炎症相关 > 5-Acetylsalicylic acid

                                5-Acetylsalicylic acid

                                5-乙酰基水杨酸

                                收藏商品 产品说明书
                                货号 abs817627
                                规格 价格
                                ¥268
                                库存?#21050;?/span>1-2周
                                ¥368
                                库存?#21050;?/span>1-2周
                                ¥648
                                库存?#21050;?/span>1-2周
                                ¥1028
                                库存?#21050;?/span>1-2周

                                数量:

                                订购信息
                                您可?#28304;?#25105;们的授权经销商处购买absin产品或获得技术支持。若要查看您所在地区的经销商,请从以下的下拉列表中选择。
                                产品介绍 商品评论 FAQ
                                概述
                                描述

                                Acetylsalicylic acid, also knows as aspirin, is an aminosalicylate anti-inflammatory drug used to treat inflammatory bowel disease, including ulcerative colitis, inflamed anus or rectum, and to maintain remission in Crohn's disease.

                                别名 5-乙酰基水杨酸
                                性能
                                外观 白色固体
                                保存方法 store at -20℃ for one year(Powder);
                                in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
                                纯度 >98%
                                分子量 180.16
                                分子结构式
                                化学式 C9H8O4
                                溶解性 10 mM in DMSO
                                CAS号 13110-96-8
                                生物活性
                                In vitro 5-Acetylsalicylic acid (5-ASA) is initially shown to downregulate the inducible cyclooxygenase/prostaglandin E2 (COX-2/PGE2) signalling in mucosa inflammatory cells. Generally 5-ASA decreases the nuclear factor κB (NF-κB) activity induced by TNF-α, modulating the NF-κB inhibitor, IκBα, as well as the NF-κB transcriptional activity induced by IL-1, although it does prevent neither IL-1-induced IκBα degradation nor IL-1-induced nuclear translocation of NF-κB family members. 5-ASA is also found to increase β-catenin expression/phosphorylation and the expression of μ-protocadherin in intestine cells while reducing the expression of Wnt/β-catenin target genes and the activity of the protein phosphatase 2A. 5-ASA enhances PPAR-γ expression/activity in intestine cells and promotes its translocation from the cytoplasm to the nucleus -- this is followed by the induction of the tumour suppressor gene PTEN, the activation of caspases 8 and 3, and the inhibition of antiapoptotic proteins. It induces membranous expression of E-cadherin and increases cell adhesion through inhibition of p-21 activated kinase-1 and modulation of N-glycosylation; Also interferes with the mitogen activated protein kinase and phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt pathways.
                                In vivo 5-ASA is rapidly adsorbed and extensively acetylated to N-acetyl-5-ASA by the N-acetyltransferase 1 enzyme in intestinal epithelial cells and the liver. It is generally well tolerated and the most common side effects include headache, nausea, and abdominal pain.
                                参考文献

                                1. Ulu N, et al. Turk J Med Sci. 2015;45(4):812-9.


                                捕鱼技巧

                                <th id="fxuvs"><meter id="fxuvs"><dfn id="fxuvs"></dfn></meter></th>
                                  <track id="fxuvs"></track><th id="fxuvs"></th>
                                  <span id="fxuvs"><big id="fxuvs"><sub id="fxuvs"></sub></big></span>
                                  <sub id="fxuvs"></sub>
                                    <track id="fxuvs"></track><th id="fxuvs"><meter id="fxuvs"></meter></th>

                                      <th id="fxuvs"><meter id="fxuvs"><listing id="fxuvs"></listing></meter></th>

                                                <th id="fxuvs"><meter id="fxuvs"></meter></th>

                                                <th id="fxuvs"><meter id="fxuvs"><listing id="fxuvs"></listing></meter></th>

                                                <th id="fxuvs"><progress id="fxuvs"></progress></th>

                                                    <address id="fxuvs"><big id="fxuvs"></big></address>

                                                    <th id="fxuvs"></th>

                                                    <nobr id="fxuvs"></nobr>

                                                    <thead id="fxuvs"><meter id="fxuvs"></meter></thead>
                                                    <track id="fxuvs"></track>

                                                    <sub id="fxuvs"></sub>

                                                    <track id="fxuvs"></track>

                                                    <track id="fxuvs"><form id="fxuvs"></form></track>

                                                    <sup id="fxuvs"><ins id="fxuvs"></ins></sup>
                                                    <dl id="fxuvs"><ins id="fxuvs"></ins></dl>

                                                    <div id="fxuvs"><tr id="fxuvs"><mark id="fxuvs"></mark></tr></div>

                                                    <sup id="fxuvs"></sup>

                                                    <dfn id="fxuvs"><tr id="fxuvs"></tr></dfn>
                                                    <div id="fxuvs"></div><sup id="fxuvs"></sup>
                                                    <em id="fxuvs"></em>

                                                    <em id="fxuvs"><ins id="fxuvs"></ins></em>

                                                        <div id="fxuvs"><tr id="fxuvs"></tr></div>

                                                          <em id="fxuvs"></em>

                                                          <dl id="fxuvs"><menu id="fxuvs"><form id="fxuvs"></form></menu></dl><div id="fxuvs"></div>
                                                              <sup id="fxuvs"><menu id="fxuvs"></menu></sup>
                                                              <div id="fxuvs"><tr id="fxuvs"></tr></div>

                                                              <sup id="fxuvs"></sup><div id="fxuvs"></div>

                                                              <sup id="fxuvs"><meter id="fxuvs"></meter></sup>

                                                              <th id="fxuvs"><meter id="fxuvs"><dfn id="fxuvs"></dfn></meter></th>
                                                                <track id="fxuvs"></track><th id="fxuvs"></th>
                                                                <span id="fxuvs"><big id="fxuvs"><sub id="fxuvs"></sub></big></span>
                                                                <sub id="fxuvs"></sub>
                                                                  <track id="fxuvs"></track><th id="fxuvs"><meter id="fxuvs"></meter></th>

                                                                    <th id="fxuvs"><meter id="fxuvs"><listing id="fxuvs"></listing></meter></th>

                                                                              <th id="fxuvs"><meter id="fxuvs"></meter></th>

                                                                              <th id="fxuvs"><meter id="fxuvs"><listing id="fxuvs"></listing></meter></th>

                                                                              <th id="fxuvs"><progress id="fxuvs"></progress></th>

                                                                                  <address id="fxuvs"><big id="fxuvs"></big></address>

                                                                                  <th id="fxuvs"></th>

                                                                                  <nobr id="fxuvs"></nobr>

                                                                                  <thead id="fxuvs"><meter id="fxuvs"></meter></thead>
                                                                                  <track id="fxuvs"></track>

                                                                                  <sub id="fxuvs"></sub>

                                                                                  <track id="fxuvs"></track>

                                                                                  <track id="fxuvs"><form id="fxuvs"></form></track>

                                                                                  <sup id="fxuvs"><ins id="fxuvs"></ins></sup>
                                                                                  <dl id="fxuvs"><ins id="fxuvs"></ins></dl>

                                                                                  <div id="fxuvs"><tr id="fxuvs"><mark id="fxuvs"></mark></tr></div>

                                                                                  <sup id="fxuvs"></sup>

                                                                                  <dfn id="fxuvs"><tr id="fxuvs"></tr></dfn>
                                                                                  <div id="fxuvs"></div><sup id="fxuvs"></sup>
                                                                                  <em id="fxuvs"></em>

                                                                                  <em id="fxuvs"><ins id="fxuvs"></ins></em>

                                                                                      <div id="fxuvs"><tr id="fxuvs"></tr></div>

                                                                                        <em id="fxuvs"></em>

                                                                                        <dl id="fxuvs"><menu id="fxuvs"><form id="fxuvs"></form></menu></dl><div id="fxuvs"></div>
                                                                                            <sup id="fxuvs"><menu id="fxuvs"></menu></sup>
                                                                                            <div id="fxuvs"><tr id="fxuvs"></tr></div>

                                                                                            <sup id="fxuvs"></sup><div id="fxuvs"></div>

                                                                                            <sup id="fxuvs"><meter id="fxuvs"></meter></sup>
                                                                                            厦门抓赌最新报 竞彩足球任选九 15选5走势图连线 老时时彩360开奖结果 秒速时时欢迎手机版 重庆时时开奖直播 481最近300期走势图 福建时时网 11选5杀号定胆专家 浙福彩12选5走势 ipad 长春麻将 时时彩高手刷流水方案 ag真人投注平台 香港麻将怎么打 南粤36选7的选号技巧 管理十三水群规