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                                5-Acetylsalicylic acid

                                5-乙酰基水杨酸

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                                货号 abs817627
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                                ¥268
                                库存?#21050;?/span>1-2周
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                                概述
                                描述

                                Acetylsalicylic acid, also knows as aspirin, is an aminosalicylate anti-inflammatory drug used to treat inflammatory bowel disease, including ulcerative colitis, inflamed anus or rectum, and to maintain remission in Crohn's disease.

                                别名 5-乙酰基水杨酸
                                性能
                                外观 白色固体
                                保存方法 store at -20℃ for one year(Powder);
                                in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
                                纯度 >98%
                                分子量 180.16
                                分子结构式
                                化学式 C9H8O4
                                溶解性 10 mM in DMSO
                                CAS号 13110-96-8
                                生物活性
                                In vitro 5-Acetylsalicylic acid (5-ASA) is initially shown to downregulate the inducible cyclooxygenase/prostaglandin E2 (COX-2/PGE2) signalling in mucosa inflammatory cells. Generally 5-ASA decreases the nuclear factor κB (NF-κB) activity induced by TNF-α, modulating the NF-κB inhibitor, IκBα, as well as the NF-κB transcriptional activity induced by IL-1, although it does prevent neither IL-1-induced IκBα degradation nor IL-1-induced nuclear translocation of NF-κB family members. 5-ASA is also found to increase β-catenin expression/phosphorylation and the expression of μ-protocadherin in intestine cells while reducing the expression of Wnt/β-catenin target genes and the activity of the protein phosphatase 2A. 5-ASA enhances PPAR-γ expression/activity in intestine cells and promotes its translocation from the cytoplasm to the nucleus -- this is followed by the induction of the tumour suppressor gene PTEN, the activation of caspases 8 and 3, and the inhibition of antiapoptotic proteins. It induces membranous expression of E-cadherin and increases cell adhesion through inhibition of p-21 activated kinase-1 and modulation of N-glycosylation; Also interferes with the mitogen activated protein kinase and phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt pathways.
                                In vivo 5-ASA is rapidly adsorbed and extensively acetylated to N-acetyl-5-ASA by the N-acetyltransferase 1 enzyme in intestinal epithelial cells and the liver. It is generally well tolerated and the most common side effects include headache, nausea, and abdominal pain.
                                参考文献

                                1. Ulu N, et al. Turk J Med Sci. 2015;45(4):812-9.


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